Brazil have managed to do without Neymar so far, and must continue to do so today and for the remainder of the tournament following his four game ban earlier in the competition.
The Brazilians managed to navigate their way past Venezuela in their last game, winning 2-1, and will hope they can continue to improve as the Copa America progresses. Meanwhile, Paraguay are undefeated at the tournament this year so far, and will believe they can do what Colombia managed to do and upset the Brazilians.
Many Brazil fans held their breath in the wake of Neymar's ban, remembering what happened last year at the World Cup when they lost Neymar - they went on to lose 1-7 to Germany in probably the most memorable game of last summer's tournament.
However, so far there have been no signs such a disintegration the team will occur. Willian has said: "There isn't really any difference in our manner. With or without Neymar, I will try to play my best football."
Arguably no team is as good as Germany at this year's Copa America, so perhaps Brazil fans won't have to worry about such a scoreline recurring, but they still fear losing to a supposed lesser side.
Brazil will know all about how dangerous Paraguay are, having been knocked out by them in a penalty shoot out at the quarter finals stage of the last Copa America.
Today's huge Copa America 2015 quarter final game between Brazil and Paraguay has a scheduled start time of 5.30 p.m. ET and can be watched on TV on the beIN Sports network or online through free live stream by clicking here.