Coach Peter Boss wants to win the match in an attempt to reconcile the yellow fans after losing the Super Cup against Bayern Munich on penalties.
Osman Dembili, the team's player, is absent from the match after a suspension from the club due to his absence from training amid growing talk about his possible move to Barcelona.
Wolfsburg, meanwhile, will play the game in a bid to make a strong offer against a fierce opponent after avoiding a second-round defeat in the second division last season.
Bayern Munich beat Bayer Leverkusen 3-1 in the first leg of the first round of the Bundesliga at Alainzer Arena.
The two teams will face early January in the second round of the competition at Signal Arena Park.