Carlyle is believed to have traveled to Manchester after being seen by a family member in Preston on Thursday.
"We have received a report that Clark Carlyle, 37, of Preston is absent from the house," a Lancashire police statement said.
Clarke Carlisle Former Burnley and Leeds defender, has played more than 500 games for 9 clubs during his career since 1997 to 2013, suffering from mental illness according to medical reports.
He had set up a mental health charity called the Clarke Carlisle Dual Diagnostic Foundation - a case described as "mental health problems as a result of drug or alcohol abuse".
Clarke Carlisle tried to integrate into his private life since December 2014 after a battle with depression, alcoholism and gambling.
Lancashire police said he was last seen by a family member in Preston at about 2:30 pm on Thursday. Last seen was wearing a blue black jacket, a black shirt, and blue jeans.